We are aware of serious limitations in interpreting the contamination levels in the breast milk and their influence on infant's health. One of the most important limitation is that individuals are exposed to more than one factor simultaneously. The risk is dependent on the contamination level in the breast milk, the time of consumption and potential co-occurence of other negative as well as positive factors. In addition to this, the NOEL values were determined on laboratory animals in the long-term chronic trials. The exposure of nursed infants to higher levels of these contaminants occurs only for a short period. Today, there is insufficient information on the different susceptibility of infants, children and adults to toxic substances, on the pattern of pesticide disposition (metabolism, elimination) in infants and children versus adults, and between laboratory animals and humans. However, a practical solution of these problems would require development of chemical-specific information on exposure and susceptibility for each stage of life for both laboratory animals and humans.

There is no single and reliable direct way how to reduce the levels of highly persistent lipophilic compounds in the breast milk with high degree of bioacumulation. The breast milk may be seen as the latest link of the human food chain. Thus, the contamination levels measured in this matrix reflect' many years of their intake. Breast milk is the most important route of excretion of these types of compounds in human beings and other mammals. Only by reduction of their environmental levels and by avoiding occupational exposure, the reduction of their levels in breast milk may be achieved. It is the only way how to prevent the whole nursed infant from the exposure to these contaminants.